Study uncovers mechanism behind establishment of chronic infection by Hepatitis B virus
New Delhi, Apr 22 (ANI): A research has found the mechanism behind establishment and maintenance of persistent infection by Hepatitis B virus (HBV). It could help in the development of new therapeutic strategies.
HBV is a blood-borne pathogen that chronically infects approximately 350 million people worldwide, and more than 780,000 patients die annually due to HBV related liver diseases. Chronic HBV infection is associated with impaired virus-specific T-cell responses.
Myeloid-derived suppressor cells (MDSCs) are immune cells known to play a critical role in impairing anti-viral T-cell responses. In addition, the Hepatitis B e-antigen (HBeAg)- a Hepatitis B viral protein- may represent a viral strategy to establish persistent infection, but the mechanism remains largely unknown.
Researchers examined the mechanisms underlying the expansion of myeloid-derived suppressor cells (MDSCs) and the suppression of T-cell responses in persistent HBV infection. The researchers analysed the circula