Eight clubs are in Gallagher Premiership action this weekend, with Newcastle knowing that a defeat against Gloucester would see them relegated.
Northampton take on Worcester, while Saracens are likely to send out a shadow line-up against Exeter. Elsewhere, Bath face Wasps.
Here, Sportsmail has provided a guide ahead of a weekend of Gallagher Premiership action.
GLOUCESTER V NEWCASTLE (Saturday, Kingsholm, 3.0)
Newcastle must fight to avert a loss which would confirm their relegation without England flanker Mark Wilson, Vereniki Goneva, Simon Hammersley and Chris Harris.
NORTHAMPTON V WORCESTER (Saturday, Franklin’s Gardens, 3.0)
Prop Alex Waller is recalled to captain the Saints, as part of a front row also including ex-All Black tighthead Ben Franks, while ex-England centre Luther Burrell makes a final home appearance before his summer move to rugby league with Warrington.
The Warriors, having secured Premiership safety last weekend, welcome back skipper GJ van Velze at No 8.
PREDICTION: Home win.