Refrigerator malfunctions and potential contamination have left shots for the flu, HPV and polio ineffective, meaning thousands have been sent letters asking to return to be revaccinated.

Vaccines have become a hot button issue over the last several weeks.

Measles outbreaks in anti-vaccination ‘hot spots’ have sprouted up across the US, affecting 10 states.

Health officials in one of the states most affected, Washington, say demand for the measles vaccine has soared by 500 percent compared to last year.

However, as people have rushed to inoculate themselves against all diseases, health officials say they may have received compromised vaccines that weren’t stored properly.

Issues at clinics in California, Indiana, Kentucky and Ohio have affected nearly 25,000 patients, reported Kaiser Health News.

It’s raised concerns about vaccine oversight – or lack thereof – at many medical offices.

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